MovDisordV3, Main, Exploration, bibRecord, 002A68

Myocardial 123Metaiodobenzylguanidine Uptake in Genetic Parkinson's Disease

Identifieur interne : 002A68 ( Main/Exploration ); précédent : 002A67; suivant : 002A69

Myocardial 123Metaiodobenzylguanidine Uptake in Genetic Parkinson's Disease

Auteurs : Aldo Quattrone [Italie] ; Antonio Bagnato [Italie] ; Grazia Annesi [Italie] ; Fabiana Novellino [Italie] ; Letterio Morgante [Italie] ; Giovanni Savettieri [Italie] ; Mario Zappia [Italie] ; Patrizia Tarantino [Italie] ; Innocenza Claudia Ciro Candiano [Italie] ; Ferdinanda Annesi [Italie] ; Donatella Civitelli [Italie] ; Francesca Emanuela Rocca [Italie] ; Marco D'Amelio [Italie] ; Giuseppe Nicoletti [Italie] ; Maurizio Morelli [Italie] ; Alfredo Petrone [Italie] ; Piercostanzo Loizzo [Italie] ; Francesca Condino [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0115891

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Captation, Maladie héréditaire, Scintigraphie.

English descriptors

KwdEn :
- Genetic disease, Nervous system diseases, Parkinson disease, Scintigraphy, Uptake.

Abstract

Myocardial ¹²³Metaiodobenzylguanidine (MIBG) enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson's disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase ² -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the 2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preserved in all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs less frequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired in patients with different mutations in the same gene or with the same gene mutation.

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

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Le document en format XML

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Metaiodoben<sub>z</sub>
ylguanidine Uptake in Genetic Parkinson's Disease</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Myocardial <sup>123</sup>
Metaiodoben<sub>z</sub>
ylguanidine Uptake in Genetic Parkinson's Disease</title>
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<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
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<author><name sortKey="Ciro Candiano, Innocenza Claudia" sort="Ciro Candiano, Innocenza Claudia" uniqKey="Ciro Candiano I" first="Innocenza Claudia" last="Ciro Candiano">Innocenza Claudia Ciro Candiano</name>
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<author><name sortKey="Annesi, Ferdinanda" sort="Annesi, Ferdinanda" uniqKey="Annesi F" first="Ferdinanda" last="Annesi">Ferdinanda Annesi</name>
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<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Civitelli, Donatella" sort="Civitelli, Donatella" uniqKey="Civitelli D" first="Donatella" last="Civitelli">Donatella Civitelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurological Sciences, National Research Council, Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emanuela Rocca, Francesca" sort="Emanuela Rocca, Francesca" uniqKey="Emanuela Rocca F" first="Francesca" last="Emanuela Rocca">Francesca Emanuela Rocca</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurological Sciences, National Research Council, Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="D Amelio, Marco" sort="D Amelio, Marco" uniqKey="D Amelio M" first="Marco" last="D'Amelio">Marco D'Amelio</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Clinical Neurosciences, University of Palermo</s1>
<s2>Palermo</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Palermo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurological Sciences, National Research Council, Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurology, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurosciences, Azienda Ospedaliera</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loizzo, Piercostanzo" sort="Loizzo, Piercostanzo" uniqKey="Loizzo P" first="Piercostanzo" last="Loizzo">Piercostanzo Loizzo</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Azienda Ospedaliera</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurological Sciences, National Research Council, Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetic disease</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Scintigraphy</term>
<term>Uptake</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Captation</term>
<term>Maladie héréditaire</term>
<term>Scintigraphie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Myocardial <sup>123</sup>
Metaiodobenzylguanidine (MIBG) enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson's disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase <sup>2</sup>
 -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the 2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preserved in all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs less frequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired in patients with different mutations in the same gene or with the same gene mutation.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
</noRegion>
<name sortKey="Annesi, Ferdinanda" sort="Annesi, Ferdinanda" uniqKey="Annesi F" first="Ferdinanda" last="Annesi">Ferdinanda Annesi</name>
<name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<name sortKey="Bagnato, Antonio" sort="Bagnato, Antonio" uniqKey="Bagnato A" first="Antonio" last="Bagnato">Antonio Bagnato</name>
<name sortKey="Ciro Candiano, Innocenza Claudia" sort="Ciro Candiano, Innocenza Claudia" uniqKey="Ciro Candiano I" first="Innocenza Claudia" last="Ciro Candiano">Innocenza Claudia Ciro Candiano</name>
<name sortKey="Civitelli, Donatella" sort="Civitelli, Donatella" uniqKey="Civitelli D" first="Donatella" last="Civitelli">Donatella Civitelli</name>
<name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<name sortKey="D Amelio, Marco" sort="D Amelio, Marco" uniqKey="D Amelio M" first="Marco" last="D'Amelio">Marco D'Amelio</name>
<name sortKey="Emanuela Rocca, Francesca" sort="Emanuela Rocca, Francesca" uniqKey="Emanuela Rocca F" first="Francesca" last="Emanuela Rocca">Francesca Emanuela Rocca</name>
<name sortKey="Loizzo, Piercostanzo" sort="Loizzo, Piercostanzo" uniqKey="Loizzo P" first="Piercostanzo" last="Loizzo">Piercostanzo Loizzo</name>
<name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
<name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Savettieri, Giovanni" sort="Savettieri, Giovanni" uniqKey="Savettieri G" first="Giovanni" last="Savettieri">Giovanni Savettieri</name>
<name sortKey="Tarantino, Patrizia" sort="Tarantino, Patrizia" uniqKey="Tarantino P" first="Patrizia" last="Tarantino">Patrizia Tarantino</name>
<name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Myocardial 123Metaiodobenzylguanidine Uptake in Genetic Parkinson's Disease

Myocardial 123Metaiodobenzylguanidine Uptake in Genetic Parkinson's Disease

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